Academic Reports Delivered by Professor Lei Cheng and Researcher Wang Du from Wuhan University

At the invitation of Professor Huang Tianye of the School of Mechanical Engineering and Electronic Information, Professor Lei Cheng and Researcher Wang Du from Wuhan University delivered academic reports for our University.

Title: Cell detection based on optical fluidic control time-domain stretch imaging (Lei Cheng)

         Terahertz Molecular Gas Laser Technology and Progress (Wang Du)

Reported by: Lei Cheng, Wang Du

Report time: 9:00 a.m. - 13:00 a.m., October 28, 2022 (Friday)

Report form: Tencent Meeting 819-527-222

Profile of the reporter:

Lei Cheng, PhD, the winner of National Talent Plan Program, is a professor and the deputy dean of The Institute of Technological Sciences of Wuhan University, Executive Director of Hubei/Wuhan Laser Association, and young editorial board member of China Laser Press. He graduated from the Department of Electronics and Information Engineering, Huazhong University of Science and Technology with a bachelor’s degree in engineering in 2008, graduated from the Department of Electronic Engineering, Tsinghua University with a PhD in Engineering in 2013, and then worked at Tsinghua University and the University of Tokyo, Japan, as a postdoctoral fellow and assistant professor. He joined the Institute of Technological Science of Wuhan University in September 2018 and has been working there since then. Professor Lei Cheng has been engaged in the research of ultrafast optical imaging systems and their applications for a long time, published more than 70 papers in high-level journals such as Nature Protocols, Nature Photonics and Cell, and has applied for and obtained 15 invention patents. He has received many awards, including the “Optical Paper Award” of the Optical Society of Japan and the first prize for technological invention of the Chinese Society for Optical Engineering.

Report summary:

As the basic unit of organism, the cell has been of wide interest to medical practitioners as well as scientific researchers. Cells are characterized by large numbers and diverse properties, requiring cell detection methods with both large throughput and high accuracy. Optical time-domain stretching imaging technology enables high-speed image acquisition of high-speed flowing cells with a spatial resolution up to 780 nm and a throughput of more than one million (106) cells per second through the comprehensive utilization of frequency-space mapping technology and frequency-time mapping technology. After acquiring a large number of cell images, the acquired cell images can be analyzed using artificial intelligence methods, and over 1,000 feature volumes can be extracted from each cell image for the recognition of specific cell features with an accuracy of up to 96%. The specificity of this method for cell analysis comes from the deep mining of cell image information, so the cells to be tested can be directly fed into the imaging system for observation without fluorescent staining and other labeling processes, avoiding the influence of fluorescent labeling on the cells, maintaining the activity of the cells, making the imaging results as close as possible to the real state of the cells, and providing the possibility of continued cell culture and research after the detection. At present, the technology has achieved preliminary application results in bioenergy preparation, disease detection, drug screening and drug resistance detection.

Profile of the reporter: 

Wang Du, researcher and doctoral supervisor of the Institute of Technological Sciences of Wuhan University, has been engaged in the scientific research on gas laser technology, terahertz science and technology, and laser advanced manufacturing for a long time. He is a senior member of the Chinese Optical Society, a member of the Laser Processing Committee of COS, and a distinguished professor of Hubei Fiber Laser Industry Alliance. He once worked at the Laser Fusion Research Center of China Academy of Engineering Physics. He has presided over more than ten national, provincial and ministerial scientific research projects, such as the National Natural Science Foundation of China, the State Administration of Science, Technology and Industry for National Defense, the key research and development plan of Hubei Province, the foundation strengthening project of the Commission of Science, Technology and Industry of the Central Military Committee of the People's Republic of China, the “Unveiling” project of Hubei Province, and the key laboratory fund. He has published more than 30 SCI papers, was authorized 23 invention patents, won one second prize of Hubei Provincial Science and Technology Progress, and one second prize and one third prize for Army Science and Technology Progress.

Report summary:

In the far infrared terahertz band, molecular gas laser (OPML) based on rotational energy level transition is an important coherent light source, which has the advantages of high power (continuous power>1W), wide frequency point coverage (0.2-10THz), and narrow linewidth (<10kHz). Traditional OPML usually uses a branch tuned CO2 laser as the pump source, including pulsed TEA CO2 laser, axial flow CO2 laser and RF slab CO2 laser. In recent years, OPML has achieved a series of new results in mid-infrared QCL pumping, continuous gas spectral line tuning, etc., which are of interest to researchers. This report provides a review and outlook on the current status and latest progress of research and application of OPML at home and abroad as well as in our group.

 School of Mechanical Engineering and Electronic Information 

Oct. 26, 2022